Cooling Agent WS-12 | Maximum Intensity Throat Cooling
Product Overview
What Is Cooling Agent WS-12?
Cooling Agent WS-12 is a food-grade synthetic cooling agent. Its chemical name is N-(4-Methoxyphenyl)-p-menthane-3-carboxamide. It comes from the menthol family, yet it ranks as the strongest agent in the WS series.
First, WS-12 stays virtually odorless and tasteless. Therefore, it cools without adding any mint aroma or bitterness. Second, it activates the TRPM8 cold receptor on the tongue and the roof of the mouth. As a result, the cooling rises to a higher intensity than any other WS grade.
Third, WS-12 brings a distinctive throat-focused sensation. In other words, the coolness reaches the back of the mouth and the throat, where menthol cannot go. It also holds FEMA number 4681 and CAS number 68489-09-8. Consequently, formulators choose it whenever the brief calls for maximum intensity.
Technical Specifications
| Item | Specification |
| Product Name (EN) | Cooling Agent WS-12 |
| Chemical Name | (2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboxamide |
| Synonyms | WS-12; N-(4-Methoxyphenyl)-p-menthane-3-carboxamide |
| CAS Number | 68489-09-8 |
| FEMA Number | 4681 |
| Molecular Formula | C18H27NO2 |
| Molecular Weight | 289.41 g/mol |
| Appearance | White crystals / crystalline powder |
| Odor | Mild cooling, slight menthol note; almost odorless |
| Taste | High-intensity cooling without bitterness |
| Assay (Purity) | >= 99.0% (HPLC) |
| Melting Point | 179 – 183 °C |
| Flash Point | > 100 °C |
| Refractive Index | 1.528 |
| Solubility | Soluble in ethanol, methanol, ethyl acetate, DMF and acetonitrile; insoluble in water |
| Cooling Duration | 15 – 30 minutes |
| Cooling Character | Highest intensity in the WS series, with a throat-focused sensation across the whole mouth |
| Recommended Dosage | 30 – 100 mg/kg in most finished products; adjust to the target cooling intensity |
| Heat Stability | Stable up to 200 °C; melting point 179 – 183 °C |
| Category | Cooling Agents |
| Storage Conditions | Store in a cool, dry place. Keep away from direct light and heat. Close the package tightly after use. |
| Shelf Life | 24 months when stored properly |
Applications & Uses
E-Liquid, Vape & Tobacco Applications
Cooling Agent WS-12 delivers its throat-focused coolness in:
- E-liquids and vape juice
- Nicotine pouches and oral nicotine products
- Tobacco products and cigarette filter tips
- Heat-not-burn tobacco sticks
- Cooling flavor concentrates
Bakery & High-Temperature Applications
The high melting point also supports:
- Baked goods and cookies
- Bread and extruded snacks
- Hot-fill beverages and canned drinks
- Pasteurized and UHT products
- Instant drink mixes and sachets
Confectionery & Oral Care Applications
Formulators commonly add WS-12 to:
- Chewing gum and bubble gum
- Hard candy and pressed candy
- Lozenges and throat drops
- Chocolate and compound coatings
- Gummies and jelly
- Toothpaste and whitening gel
- Mouthwash and breath freshener
- Breath strips and oral sprays
Personal Care & Pharmaceutical Applications
WS-12 also supports:
- Skin cream and body lotion
- Face mask and cooling gel
- Shaving cream and after-shave
- Shampoo and scalp care
- Sunscreen and after-sun lotion
- Lip balm
- Air freshener
- OTC liniments and cooling balms
- Throat syrups and cough drops
- Cooling patches and plasters
- OEM flavor and cooling blends
Certifications & Compliance
We can provide the following quality and product documents:
- ISO 9001:2015 — Quality Management System
- ISO 22000 — Food Safety Management
- GMP — GMP-aligned manufacturing facility
- HALAL — Certified batches available
- KOSHER — Certification available upon request
- COA / MSDS / TDS — Product documents available for each lot
- FEMA 4681 / FEMA GRAS — Flavor industry listings
- Non-Restricted Cargo — Standard export classification
- Third-party laboratory testing — SGS, Eurofins or your selected laboratory
Frequently Asked Questions
What is Cooling Agent WS-12, and how does it cool?
Cooling Agent WS-12 is N-(4-Methoxyphenyl)-p-menthane-3-carboxamide, a synthetic cooling agent with CAS number 68489-09-8. It activates the TRPM8 cold receptor on the tongue and the roof of the mouth. As a result, you feel the strongest cooling in the WS series, and the sensation reaches the throat as well. The effect lasts 15 to 30 minutes.
How does WS-12 differ from WS-3, WS-5 and WS-23?
WS-12 delivers the highest intensity of the four, and it cools the throat as well as the mouth. WS-3 gives a clean, immediate impact that lasts 15 to 30 minutes. On the other hand, WS-23 delivers a sharper, front-loaded burst. In contrast, WS-5 spreads a smooth, long-acting wave across the whole mouth. Therefore, many formulators blend WS-12 with WS-23 for e-liquids and with WS-5 for chewing gum.
Why does the melting point matter?
WS-12 melts at 179 to 183 °C, and it holds full cooling power even at 200 °C. Because of this, it suits baking, extrusion and hot-fill processes. By contrast, most other cooling agents lose impact under the same conditions.
Need specifications, COA, or a wholesale quote? Contact Us — typical response within 24 hours.